Projecte: SARS-CoV-2 specific T cell donor bank.
Responsabilitats i funcions principals
Estudiar la resposta immunològica cel·lular contra el SARS-CoV-2, mitjançant la caracterització de les cèl·lules T en donants immunitzats, així com desenvolupar línies de cèl·lules T específiques, per a crear un banc de limfòcits T específics contra SARS-CoV-2.
Mèrits a valorar
Oferim un lloc de treball amb les següents característiques:
Procés de selecció
Els candidats interessats hauran d'adjuntar a la següent adreça, una carta de presentació, un curriculum vitae complet i un mínim de 2 referències: email@example.com
The Mouse Models of Cancer Therapies group from VHIO seeks a PhD student to join our group
Application deadline: 13/9/2020
The Mouse Models of Cancer Therapies group led by ICREA Research Professor Laura Soucek is seeking an excellent and highly motivated PhD student to join us on a project supported by La Marató Foundation to study the role of Myc in instructing the tumor immune microenvironment in Non-Small-Cell Lung Cancer (NSCLC) with diverse mutational landscapes.
The group’s main interest is the role of Myc in tumorigenesis and Myc inhibition as a valuable approach in cancer therapy. Its main lines of research are (i) Myc-induced tumorigenesis, (ii) Myc inhibition and its validation as cancer therapy, (iii) design and testing of clinically-viable protein-based Myc inhibitors, (iv) development of pre-clinical models of cancer therapy and (v) Myc-induced cancer immune evasion.
The laboratory regularly works with several transgenic, syngeneic, humanized and patient-derived xenograft (PDX) mouse models of cancer, including lung, glioma, breast, colorectal, melanoma, Burkitt’s lymphoma and multiple myeloma models, with a very translational approach. The group overarching goal is to bring Myc inhibition to the clinic.
We are seeking enthusiastic, highly motivated and qualified PhD students. Candidates must have an exceptional academic record and hold a Master’s Degree to be eligible for highly competitive fellowships. A background in immunology /immune-oncology will be favorably considered.
Education and qualifications
• Degree in life sciences
• Master’s Degree in life sciences
Experience and knowledge
• Previous experience in at least one research laboratory
• Animal Experimentation Certificate is preferred
• Experience in cell culture, flow cytometry and mouse handling is preferred
• Excellent organization and communication skills
• Ability to work independently as well as part of a team
• High level of English
Main responsibilities and duties
• Planning and execution of research projects under supervision
• Use of immunology and cell culture techniques, as well as handling of different animal models
• Presentation of research results at internal and external meetings
To join our group and contribute to this exciting research project, applicants should send a CV, contact information of at least one reference and a cover letter describing past achievements and research interests to: Sílvia Casacuberta firstname.lastname@example.org and Jonathan Whitfield email@example.com
JOB POSITION: POSTDOCTORAL FELLOW-COVID19 PROJECT: The B cell biology group at IMIM is looking for a highly motivated postdoctoral fellow with a keen interest inthe antibody mediated immune response in COVID19.THE LABORATORY:The laboratory is located at IMIM Foundation (https://www.imim.es). This center is an integral part of thePRBB, one of the largest biomedical research clusters in Southern Europe. PRBB provides an intellectuallystimulating environment that hosts nearly one thousand scientists organized in eighty different researchgroups (http://www.prbb.org).
WHAT WE OFFER:We offer a very stimulating and welcoming working environment in a highly competitive research groupdedicated to the analysis of the cellular and signaling networks underlying mature B cell responses,including immunoglobulin heavy chain class switching and somatic hypermutation.Most relevant publication in the last 5 years: Chen K et al Nat Rev Immunol 2020; Sintes J. et al. NatureCommunication 2017; Magri G et al. Immunity 2017; Magri G et al. Nature Immunology 2014
THE PROJECT: https://www.biocat.cat/en/current-news/blog/5-covid-19-therapies-catalan-research
TASKS:The selected candidate will study the antibody response to SARS-CoV-2 in COVID19 patients by highdimension immune profiling of peripheral blood B cells populations and serological assays. The candidatewill also generate SARS-CoV-2 specific monoclonal antibodies using a strategy that involves amplificationand cloning of the variable portion of the B cell receptor from B cells of highly responder COVID19+patients. The selected candidate will be on charge, along with the PI, of the experimental part of the projectas well as the analysis, processing and the dissemination of results.
STUDIES:PhD in biomedicine, immunology, molecular biology or related fields
EXPERIENCE and KNOWLEDGE: Wide experience and knowledge in the following lab techniques are highly recommended: flowcytometry and FACsorting, ELISA, cloning and molecular biology, cell culture, blood sample processingand PBMC isolation• Candidate should have excellent communication and multi-tasking skills, be team oriented and proactive• Candidate must be proficient in oral and written English
CONDITION:This is a 1-year appointment with possibility of renewal based upon satisfactory job performance,continuing availability of funds, and on-going operational needs.
APPLICATION PROCESS:All application will be welcome irrespective of race, nationality, gender or sexual orientation.
Application in: https://www.imim.es/ofertes-treball/view_contracte.php?id=1537
Enquiries should be sent to firstname.lastname@example.org (Dr. Giuliana Magri) indicating “postdoc call 2020” in thesubject