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Ofertes de treball

Post-Doctoral Position in Deconvoluting the Microenvironment in Cancer (University of Edinburgh).

Data Publicació: 13-06-2022
Referència: 13492
Descripció:

Professor Jeffrey Pollard at the Centre for Reproductive Health at the University of Edinburgh is looking for post-doctoral positions to join his lab immediately.

We are looking for a highly motivated and independent researcher to join a team working on the tumour microenvironment and particularly the role of macrophages, in cancer progression and metastasis. The candidate will be expected to have a record of good publications and to be interested in immunity. Studies will focus on breast cancer using fresh clinical and archival material, induced pluripotent stem cell derived macrophages and animal models. An understanding of imaging techniques would be an advantage. However, most important is creativity the ability and drive to work independently and an interest in tumour immunity.

Relevant Publications

1 - Cassetta, L. et al. Human Tumor-Associated Macrophage and Monocyte Transcriptional Landscapes Reveal Cancer-Specific Reprogramming, Biomarkers, and Therapeutic Targets. Cancer cell 35, 588-602 e510, doi:10.1016/j.ccell.2019.02.009 (2019).

2 - Guc, E. & Pollard, J. W. Redefining macrophage and neutrophil biology in the metastatic cascade. Immunity 54, 885-902, doi:10.1016/j.immuni.2021.03.022 (2021).

3 - Robinson, A. et al. Systemic Influences of Mammary Cancer on Monocytes in Mice. Cancers (Basel) 14, doi:10.3390/cancers14030833 (2022).

Please send your applications to: Professor Jeffrey Pollard, Jeff.Pollard@ed.ac.uk

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Post-doctoral research associate - Immunology/systems biology (King's College London).

Data Publicació: 16-05-2022
Referència: 13373
Descripció:

Job description

This post will based in the Inflammation Biology Group headed by Prof. Toby Lawrence at the Centre for Inflammation Biology & Cancer Immunology (CIBCI) and in close collaboration with the Systems Cancer Immunology Group headed by Dr. Shahram Kordasti, both based at Guy’s Hospital campus. CIBCI aims to leverage expertise in inflammation biology to extend fundamental and applied knowledge of tumour immunobiology. In this context, the post holder will develop projects applying novel work flows and analytical pipelines for the acquisition of multidimensional data sets, including single cell RNA sequencing, imaging mass cytometry and spatial transcriptomics, from both patient samples and experimental models, with the ultimate goal of deconstructing the roles of myeloid cells in the tumour immune-microenvrionment and their bearing on cancer using functional genomics. The post holder will also be involved in the training and supervision of PhD students and junior research associates involved in related projects.

This post will be offered on a 3 years fixed-term contract with the possibility to extend for a further 2 years

This is a full-time post.

Key responsibilities

• To work on the immunological and molecular profiling of patient samples and tissues from animal models and patients.

• To develop mechanistic insights derived from such profiling activities in collaboration with clinical and basic scientists

• To use a variety of technologies to investigate the functional immunological status of cancers and the influence of their microenvironments

• To create, implement and use analytical and bioinformatics tools to analyse and interpret multidimensional data.

• To establish the pipelines for collection and analysis of patient samples and enable the development of experimental protocols.

• To support writing of grants and manuscripts for maintaining the continual research in this domain.

• To promote research initiatives and original contributions to the research programmes of the Centre, Department, School and Faculty.

• Design and implement systems for laboratory information management (both electronic and manual) and archiving of analytical material.

• Develop and improve their own scientific knowledge and awareness of developments within the field of molecular and cellular immunology via attendance of relevant meetings and conferences, both nationally and internationally.

• Develop original novel research projects based on thorough assessment of the published literature and advice from the head of the research group (Prof Lawrence).

• Prepare grant applications, project justifications, business cases and project reports.

• Prepare manuscripts for publication in peer reviewed academic journals.

• Present research work at national and international meetings promoting the department whilst making useful contacts within the field, and to engage other scientists in strategy development.

• Routinely supervise and train junior scientific and technical staff, students and visiting members of staff working in the laboratory.

• Facilitate the professional development of junior staff through a mentoring approach.

Skills knowledge, and experience

Essential criteria

• PhD awarded in relevant discipline, or equivalent

• Knowledge of relevant platforms and techniques

• Knowledge of immunology, any previous lab experience is advantageous.

• Knowledge/skills in the use of platforms monitoring patient immunological and/or microenvironment status

• Past peer-reviewed publications(s) that involves the use of platforms monitoring patient immunological and/or microenvironment status

• Advanced skills with Microsoft Packages such as Word and Excel

• Knowledge of computational biology

• Numeracy skills as required for the statistical analysis of experimental data, including familiarity with a specialist statistical software package (i.e. SPSS or similar)

• Ability to analyse data with existing publicly available and commercial software solutions (e.g. R/Bioconductor, UMAP, viSNE, SPADE, FlowJo, CytoBank suite)

• Develop novel tools using statistics, mathematics and machine learning approaches for the analysis of high dimensional data.

• Interest in the field of translation cancer research

Desirable criteria

• Leadership – able to motivate others, encourage teamwork, delegate, and get the best out of people

• Analysis and understanding – able to analyse and evaluate evidence; e.g. in planning, problem solving and decision making

• Management of time – able to plan and use own time economically and effectively

* Please note that this is a PhD level role but candidates who have submitted their thesis and are awaiting award of their PhDs will be considered. In these circumstances the appointment will be made at Grade 5, spine point 30 with the title of Research Assistant. Upon confirmation of the award of the PhD, the job title will become Research Associate and the salary will increase to Grade 6.

Further information

https://jobs.kcl.ac.uk/gb/en/job/046151/Post-doctoral-research-associate-Immunology-systems-biology

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PostDoctoral position. Mechanisms of Peripheral Tolerance Unit ( San Raffaele Telethon Institute for Gene Therapy, Milan, Italy)

Data Publicació: 21-03-2022
Referència: 13119
Descripció:

A postdoctoral position is available in the laboratory of Mechanisms of Peripheral Tolerance led by Dr. S. Gregori at the San Raffaele Telethon Institute for Gene Therapy (SR-TIGET), Milan, Italy.. Full info at:

https://www.mye-infobank.eu/files/554-grande/img/mye-infobank/Mye-InfoBank%20Downloads/PostDoc%20Position%20GREGORI-SR-TIGET.pdf

THE POSITION. We are looking for a highly motivated and skilled researcher to work on a project entitled: “Personalized antigen-specific immunotherapy to halt autoimmunity in pre-symptomatic and symptomatic Type 1 Diabetic subjects” Grant Key: 3-SRA-2021-1007-S-B, funded by JDRF.

A postdoctoral position is available to work on a translational project foreseeing the use of state-of-the-art genetic approaches, immunological assays, and newly developed in vivo models. The project aims at investigating the in vitro modulatory activities of lentiviral vector-engineered dendritic cells (DC) from type 1 diabetes patients and to develop a novel HuMice model to study the regulatory activity of engineered DC in vivo.

Starting Date: May/June 2022

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Friedrich Loeffler Institute (Germany). Open group leader position - focus on B cell immunology in infection.

Data Publicació: 18-03-2022
Referència: 13109
Descripció:

ThFriedrich Loeffler Institute (FLI) is one of the world's leading research institutes in the field of animal diseases, animal welfare, animal husbandry, animal nutrition and farm animal genetics. It is part of the portfolio of the Federal Ministry of Food and Agriculture and informs and advises the Federal Government in these areas.

The Institute of Immunology, at the headquarters in Greifswald – Insel Riems is looking for a

Scientific Employee (m/f/d)

to start a soon as possible on a full-time basis. The position is limited to two years as part of a probationary leadership. If the candidate proves himself, he/she will be offered a permanent position.

Tasks:

The successful candidate will study the immunology of B cells during infection and will build up an independent research group. Investigations should characterize B cell populations and antibody repertoires in livestock and wildlife by combining experimental tools and bioinformatics. Analysis of antigen specificities, BCR repertoires and antibody features should promote design of novel interventions against notifiable animal diseases and/or zoonoses. Analysis of immune responses should be explored in a comparative approach, including experiments in high containment laboratories (safety level 2 and 3).

•

Investigations on B cell responses during bacterial and viral infection

•

Combine experimental tools and bioinformatics to functionally analyze BCR/antibody repertoires

•

Application of state-of-the-art and high-throughput technologies to define BCR and antibody specificities (e.g. single cell/AIR sequencing, cloning, binding assays, CRISPR/Cas9 genome editing)

•

Development of an advanced serology pipeline for livestock

Requirements:

•

University degree in biosciences

•

PhD in Immunology, Infection Biology or related Biosciences

•

Proven expertise in B cell immunology and bioinformatics

Assets for the position are:

•

Experience in development and refinement of high-content high-resolution platforms for BCR/antibody investigations

•

Experience in supervision of trainees

•

Expertise in work with infectious organisms

•

Excellent communication skills in English

For this position, the experience in establishing investigation platforms as well as methodologies are mandatory. In addition, the candidate should be capable of interdisciplinary work.

In addition to an interesting and diverse job in an international and scientifically interesting environment, we offer you to work in highly motivated multicultural and diverse team as well as an employment according to the collective agreement of the public service (pay group 14 TVöD- Bund, tarif area east).

The Friedrich Loeffler Institute is committed to a family-friendly working environment through flexible working hours and the basic option of part-time employment. Our social benefits include company health and reintegration management, company social counselling and capital-forming benefits.

The FLI is also committed to inclusion. Applications from people with severe disabilities are therefore explicitly welcome. They will be given preferential consideration in the selection process. In line with our international orientation, we welcome applications from people of all nationalities and ethnicities.

For further information, please contact Prof. Dr. Anca Dorhoi (Anca.Dorhoi@fli.de).

We look forward to receiving your application. Please send your complete application including comprehensive documents (proof of qualification, CV, list of publications, and references) as a PDF document with the subject “Stelle 023/22” to the following e-mail address: 023/22@fli.de until April 28, 2022 at the latest. Please address written applications to the Friedrich-Loeffler-Institut, Department of Human Resources, Postfach 1318 in 17466 Greifswald-Insel Riems, Germany.

Confirmation of receipt as well as communication during the application process will proceed via e-

The Friedrich Loeffler Institute (FLI) is one of the world's leading research institutes in the field of animal diseases, animal welfare, animal husbandry, animal nutrition and farm animal genetics. It is part of the portfolio of the Federal Ministry of Food and Agriculture and informs and advises the Federal Government in these areas.The Institute of Immunology, at the headquarters in Greifswald – Insel Riems is looking for aScientific Employee (m/f/d)to start a soon as possible on a full-time basis.

The position is limited to two years as part of a probationary leadership. If the candidate proves himself, he/she will be offered a permanent position.

Tasks:

•Investigations on B cell responses during bacterial and viral infection•Combine experimental tools and bioinformatics to functionally analyze BCR/antibody repertoires

•Application of state-of-the-art and high-throughput technologies to define BCR and antibody specificities (e.g. single cell/AIR sequencing, cloning, binding assays, CRISPR/Cas9 genome editing)

•Development of an advanced serology pipeline for livestock

Requirements:

•University degree in biosciences

•PhD in Immunology, Infection Biology or related Biosciences

•Proven expertise in B cell immunology and bioinformatics

Assets for the position are

:•Experience in development and refinement of high-content high-resolution platforms for BCR/antibody investigations

•Experience in supervision of trainees

•Expertise in work with infectious organisms

•Excellent communication skills in English

For this position, the experience in establishing investigation platforms as well as methodologies are mandatory. In addition, the candidate should be capable of interdisciplinary work.

The job involves working in a biosecurity environment, which requires a security clearance according to the Security Clearance Act (Sicherheitsüberprüfungsgesetz, SÜG) and special protective measures against health hazards. Mental and physical suitability is therefore a prerequisite for filling the position.In addition to an interesting and diverse job in an international and scientifically interesting environment, we offer you to work in highly motivated multicultural and diverse team as well as an employment according to the collective agreement of the public service (pay group 14 TVöD- Bund, tarif area east).

Applications from people with severe disabilities are therefore explicitly welcome. They will be given preferential consideration in the selection process. In line with our international orientation, we welcome applications from people of all nationalities and ethnicities.

For further information, please contact Prof. Dr. Anca Dorhoi (Anca.Dorhoi@fli.de).We look forward to receiving your application. Please send your complete application including comprehensive documents (proof of qualification, CV, list of publications, and references) as a PDF document with the subject “Stelle 023/22” to the following e-mail address: 023/22@fli.de until April 28, 2022 at the latest. Please address written applications to the Friedrich-Loeffler-Institut, Department of Human Resources, Postfach 1318 in 17466 Greifswald-Insel Riems, Germany.

Confirmation of receipt as well as communication during the application process will proceed via e-mail.

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