Detall notícia

El paper de la molècula CD6 en la immunoteràpia del càncer.


Lucía Aragón-Serrano, Laura Carrillo-Serradell, Violeta Planells-Romeo, Marcos Isamat, María Velasco-de Andrés i Francisco Lozano (Hospital Clínic, IDIBAPS, Universitat de Barcelona) publiquen la revisió titulada “CD6 and Its Interacting Partners: Newcomers to the Block of Cancer Immunotherapies”  (revista: International Journal of Molecular Sciences) on expliquen el paper de la molècula CD6 en diferents estratègies d’immunoteràpia per al tractament del càncer.


Cancer management still requires more potent and safer treatments, of which immunomodulatory receptors on the lymphocyte surface have started to show promise in new cancer immunotherapies (e.g., CTLA-4 and PD-1). CD6 is a signal-transducing transmembrane receptor, mainly expressed by all T cells and some B and NK cell subsets, whose endogenous ligands (CD166/ALCAM, CD318/CDCP-1, Galectins 1 and 3) are overexpressed by malignant cells of different lineages. This places CD6 as a potential target for novel therapies against haematological and non-haematological malignancies. Recent experimental evidence for the role of CD6 in cancer immunotherapies is summarised in this review, dealing with diverse and innovative strategies from the classical use of monoclonal antibodies to soluble recombinant decoys or the adoptive transfer of immune cells engineered with chimeric antigen receptors.

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